Common questions on CBD

As the market surrounding cannabinoids and CBD continues to blossom and improve the health of many,  we want to clear…

What are Cannabinoids?

HEALTHTECH — OCT 23, 2015 (Photo: medcannaman/Flickr) Cannabinoids are a group of active compounds found in marijuana. While most cannabis users…

The Future Is CBD Oil

By Maryam Henein | Posted on Feb 10, 2015 CBD oil is the future. Cannabis has been stigmatized for decades,despite proof of…

Stroke/TBI

About one million people in the United States are treated in emergency rooms each year for traumatic brain injuries, resulting…

Stress

Endogenous cannabinoid signaling is essential for stress adaptation (PubMed) Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders (PubMed) Functional…

Spinal cord injury

Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury(PubMed)

Sleep disorders

The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent(PubMed) Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex,…

Skin conditions

Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis(PubMed)…

Sickle cell anemia

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: Modulation by cannabinoids (Pub Med) Cannabis use in sickle cell disease:…

Schizophrenia

Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug (PubMed) Cannabidiol as a potential treatment for psychosis (PubMed) Cannabidiol enhances anandamide signaling…

Rheumatism

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress (PubMed)

PTSD

The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD (PubMed) Reductions in circulating endocannabinoid levels in individuals with…

Prion/Mad Cow disease

Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity (PubMed) Cannabidiol: A prion therapy for mice? (PubMed)

Parkinsons

Prospects for cannabinoid therapies in basal ganglia disorders (PubMed) Evaluation of the neuroprotective effect of cannabinoids in a rat model of…

Osteporosis

Cannabinoid receptors as target for treatment of osteoporosis: A tale of two therapies(PubMed) Cannabinoids and bone: Friend or foe? (PubMed) Cannabinoid…

OCD

Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following…

Obesity

The impact of marijuana use on glucose, insulin, and insulin resistance among US adults(PubMed) Cannabinol and cannabidiol exert opposing effects…

Neuropathic pain

Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain(PubMed) Sativex: Clinical efficacy and tolerability in the treatment of…

Neurodegeneration

Cannabidiol: A promising drug for neurodegenerative disorders? (PubMed) Cannabidiol for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid? (PubMed) Transdermal delivery…

Nausea

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system(PubMed) Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and…

MS / multiple sclerosis

Sativex for the management of multiple sclerosis symptoms (PubMed) THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated…

Motion sickness

Motion sickness, stress and the endocannabinoid system (PubMed) Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system…

Mood disorders

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders (PubMed) The endocannabinoid system and the treatment of…

Migraine

Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other…

Metabolic syndrome

The impact of marijuana use on glucose, insulin, and insulin resistance among US adults(American Journal of Medicine) The potential use…

Liver disease

The endocannabinoid system and liver diseases (PubMed) Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress,…

Kidney disease

Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death (PubMed)

Irritable bowel

Cannabidiol in inflammatory bowel diseases: A brief overview (PubMed) Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis (PubMed) Clinical endocannabinoid…

Inflammation

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress (PubMed) The endocannabinoid system: an emerging…

Huntington’s

Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease (PubMed) Cannabinoids: Novel medicines for the treatment of Huntington’s disease (PubMed)…

Heart disease

Is the cardiovascular system a therapeutic target for cannabidiol? (PubMed) Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and…

Glaucoma

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite(PubMed) Effect of sublingual application of cannabinoids on intraocular pressure:…

Fibryomalgi

Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other…

Epilepsy/seizure

CBD for children with Dravet’s and intractable seizures (Video) Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant…

Endocrine disorders

Endocannabinoid system participates in neuroendocrine control of homeostasis(PubMed) The emerging role of the endocannabinoid system in endocrine regulation and energy…

Diabetes

The impact of marijuana use on glucose, insulin, and insulin resistance among US adults(American Journal of Medicine) Cannabidiol attenuates cardiac…

Depression

Endocannabinoid system dysfunction in mood and related disorders (PubMed) Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa (PubMed)…

Chrons

Chrons & stomach problems Cannabidiol in inflammatory bowel diseases: a brief overview (PubMed) Cannabis finds its way into treatment of Crohn’s…

Cancer studies

Cannabidiol as potential anticancer drug (PubMed) Cannabidiol inhibits angiogenesis by multiple mechanisms (PubMed) The inhibitory effects of cannabidiol on systemic malignant tumors (PubMed)…

Bipolar

Cannabinoids in bipolar affective disorder: A review and discussion of their therapeutic potential (PubMed) Cannabidiol was ineffective for manic episode of…

Autism

Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain (Science Daily) Cannabinoid receptor type 2, but not…

Asthma

The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke (PubMed) Allergen challenge increases anandamide…

Atherosclerosis

The role of the endocannabinoid system in atherosclerosis (PubMed) Cannabinoid receptors in atherosclerosis (PubMed) The potential use of cannabidiol in the therapy…

Arthritis

Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by…

Antibiotic Resistance

Antibacterial cannabinoids from Cannabis sativa: A structure-activity study (PubMed) Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol (PubMed)

Anorexia

Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa(PubMed) The role of the endocannabinoid system in eating disorders: Neurochemical…

ALS

Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials (PubMed) Medical Cannabis Helps ALS Patient…

AIDS

Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium (PubMed)

ADD/ADHD

Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders (Pub Med) Cannabidiol and clozapine reverse…

Addiction Cannabidiol reduces cigarette consumption in tobacco smokers (PubMed) Cannabidiol inhibits the reward-facilitating effect of morphine (PubMed) Cannabidiol, a nonpsychotropic component of…

Alzheimer’s

The therapeutic potential of the endocannabinoid system for Alzheimer’s disease(PubMed) Endocannabinoid signalling in Alzheimer’s disease (PubMed) A molecular link between the…

Anxiety Research

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug(PubMed) Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis…