Stroke/TBI

About one million people in the United States are treated in emergency rooms each year for traumatic brain injuries, resulting … More

Stress

Endogenous cannabinoid signaling is essential for stress adaptation (PubMed) Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders (PubMed) Functional … More

Spinal cord injury

Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury(PubMed)

Sleep disorders

The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent(PubMed) Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex, … More

Skin conditions

Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis(PubMed) … More

Sickle cell anemia

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: Modulation by cannabinoids (Pub Med) Cannabis use in sickle cell disease: … More

Schizophrenia

Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug (PubMed) Cannabidiol as a potential treatment for psychosis (PubMed) Cannabidiol enhances anandamide signaling … More

Rheumatism

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress (PubMed)

PTSD

The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD (PubMed) Reductions in circulating endocannabinoid levels in individuals with … More

Prion/Mad Cow disease

Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity (PubMed) Cannabidiol: A prion therapy for mice? (PubMed)

Parkinsons

Prospects for cannabinoid therapies in basal ganglia disorders (PubMed) Evaluation of the neuroprotective effect of cannabinoids in a rat model of … More

Osteporosis

Cannabinoid receptors as target for treatment of osteoporosis: A tale of two therapies(PubMed) Cannabinoids and bone: Friend or foe? (PubMed) Cannabinoid … More

OCD

Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following … More

Obesity

The impact of marijuana use on glucose, insulin, and insulin resistance among US adults(PubMed) Cannabinol and cannabidiol exert opposing effects … More

Neuropathic pain

Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain(PubMed) Sativex: Clinical efficacy and tolerability in the treatment of … More

Neurodegeneration

Cannabidiol: A promising drug for neurodegenerative disorders? (PubMed) Cannabidiol for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid? (PubMed) Transdermal delivery … More

Nausea

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system(PubMed) Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and … More

MS / multiple sclerosis

Sativex for the management of multiple sclerosis symptoms (PubMed) THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated … More

Motion sickness

Motion sickness, stress and the endocannabinoid system (PubMed) Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system … More

Mood disorders

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders (PubMed) The endocannabinoid system and the treatment of … More

Migraine

Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other … More

Metabolic syndrome

The impact of marijuana use on glucose, insulin, and insulin resistance among US adults(American Journal of Medicine) The potential use … More

Liver disease

The endocannabinoid system and liver diseases (PubMed) Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, … More

Kidney disease

Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death (PubMed)

Irritable bowel

Cannabidiol in inflammatory bowel diseases: A brief overview (PubMed) Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis (PubMed) Clinical endocannabinoid … More

Inflammation

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress (PubMed) The endocannabinoid system: an emerging … More

Huntington’s

Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease (PubMed) Cannabinoids: Novel medicines for the treatment of Huntington’s disease (PubMed) … More

Heart disease

Is the cardiovascular system a therapeutic target for cannabidiol? (PubMed) Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and … More

Glaucoma

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite(PubMed) Effect of sublingual application of cannabinoids on intraocular pressure: … More

Fibryomalgi

Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other … More

Epilepsy/seizure

CBD for children with Dravet’s and intractable seizures (Video) Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant … More

Endocrine disorders

Endocannabinoid system participates in neuroendocrine control of homeostasis(PubMed) The emerging role of the endocannabinoid system in endocrine regulation and energy … More

Diabetes

The impact of marijuana use on glucose, insulin, and insulin resistance among US adults(American Journal of Medicine) Cannabidiol attenuates cardiac … More

Depression

Endocannabinoid system dysfunction in mood and related disorders (PubMed) Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa (PubMed) … More

Chrons

Chrons & stomach problems Cannabidiol in inflammatory bowel diseases: a brief overview (PubMed) Cannabis finds its way into treatment of Crohn’s … More

Cancer studies

Cannabidiol as potential anticancer drug (PubMed) Cannabidiol inhibits angiogenesis by multiple mechanisms (PubMed) The inhibitory effects of cannabidiol on systemic malignant tumors (PubMed) … More

Bipolar

Cannabinoids in bipolar affective disorder: A review and discussion of their therapeutic potential (PubMed) Cannabidiol was ineffective for manic episode of … More

Autism

Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain (Science Daily) Cannabinoid receptor type 2, but not … More

Asthma

The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke (PubMed) Allergen challenge increases anandamide … More

Atherosclerosis

The role of the endocannabinoid system in atherosclerosis (PubMed) Cannabinoid receptors in atherosclerosis (PubMed) The potential use of cannabidiol in the therapy … More

Arthritis

Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by … More

Antibiotic Resistance

Antibacterial cannabinoids from Cannabis sativa: A structure-activity study (PubMed) Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol (PubMed)

Anorexia

Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa(PubMed) The role of the endocannabinoid system in eating disorders: Neurochemical … More

ALS

Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials (PubMed) Medical Cannabis Helps ALS Patient … More

AIDS

Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium (PubMed)

ADD/ADHD

Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders (Pub Med) Cannabidiol and clozapine reverse … More

Anxiety Research

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug(PubMed) Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis … More